AP Biology Drugs Assignment
We have already studied the numerous differences between prokaryotic and eukaryotic organisms, as well as some differences between other organisms. You should review these differences to complete this assignment. Homo sapiens have learned to exploit the differences between organisms to be able to kill infections while not affecting the host [us].

The question is, ‘How do these molecules differentiate between the two?’. That is your job to answer. By the time you are given this assignment we will have discussed eukaryotic organisms in quite a bit of detail. We have examined differences between the domains. We have studied a number of biochemical reactions vital to life. And we have studied the molecular aspects of the ‘central dogma’ [replication, transcription and translation].

Tasks:

To collect data on the drug you choose from the list below.

To determine the characteristics of the molecule you choose:

  • class & family
  • – how is the drug classified, antibacterial? antifungal? etc. Be specific
  • describe the infectious agent in terms of its taxonomic classification
  • describe the distribution and prevalence of the infectious agent the anti-infectious kills
  • source [where does the drug come from?]

  • size – usually measured in kiloDaltons but you tell us the units you are found. Even relative size is good.

  • structure/shape – 2D or 3D picture?
  • typical dosage and duration for adult Homo sapien
  • mode of action – what and how does the drug do what it does – be specific
  • explain how the drug interferes with the organism’s life and kills it
  • explain why the drug doesn’t have the same effect on the host [humans]

Present the following in a quick five minute presentation….your choice of venue

  • power point
  • wetpaint pages
  • other? [just inform me of your idea.

Drugs List:

  • most of these are
    anti-infective agents classified into their family category:
  • the method of
    attack by these organisms varies
  1. the antihelmintics mebendazole or pyrantel
    pamoate [hint: helmint- should look familiar]
  2. the antifungal amphotericin
  3. the antifungal griseofulvin
  4. the antituberculotic rifapentine
  5. the aminoglycosides _____mycin sulfate [this is
    a family]
  6. the penicillins family [almost all of them work
    in the same manner]
  7. the cephalosporins family [these also all work
    in the same manner]
  8. the sulfanomides family [ibid]
  9. the flouroquinolone family [ibid]
  10. the antiviral abacavir sulfate
  11. the antiviral ganciclovir
  12. the antiviral ritonavir

Before the discovery of anti
infectious drugs, infectious agents were the number one killers of people in
the Western hemisphere. In many countries around the world they still are.

** Lets be sure to discuss the evolution of antibiotic resistance.

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